The effect of physical and chemical restraint on selected respiratory parameters of Macaca mulatta.

SSUMMARY * A comparison of the respiration of Macaca mulatto restrained with strait jackets or injected intramuscularly with I mg 'kg of phencyclidine hydrochloride revealed that the minute volume of the strait-jacketed animals was about 3 times that of relatively unrestrained animals when measurements were made 10, 20, and 30 minutes after treatment. The values obtained from the drug-treated animals were about 60% of those predicted by Guyton (3), and those obtained from strait-jacketed monkeys were about 200% of Guyton's predicted values. These differences were found to be statistically significant in every case. The 2 treatments also produced significantly different respiration rates (drug-treated monkeys about 67% of the strait-jacketed animals), heart rates (drug-treated rate about 84% of the jacketed monkeys), and tidal volumes (drug-treated about 52% of the jacketed animals' volumes).